{"fusion":{"id":"BCR::ABL1","partners":[{"gene":"BCR","breakpoint":null},{"gene":"ABL1","breakpoint":null}]},"hgnc":[{"symbol":"BCR","hgncId":"HGNC:1014","name":"BCR activator of RhoGEF and GTPase","uniprot":"P11274","locusType":"gene with protein product","matchedBy":"symbol"},{"symbol":"ABL1","hgncId":"HGNC:76","name":"ABL proto-oncogene 1, non-receptor tyrosine kinase","uniprot":"P00519","locusType":"gene with protein product","matchedBy":"symbol"}],"genes":[{"gene_id":"ENSG00000186716","symbol":"BCR","name":"BCR activator of RhoGEF and GTPase","chrom":"22","start":23179704,"stop":23318037,"strand":"+","canonical_transcript_id":"ENST00000305877","mane_select_transcript":{"ensembl_id":"ENST00000305877","refseq_id":"NM_004327"},"transcripts":[{"transcript_id":"ENST00000359540","strand":"+","exons":[{"feature_type":"UTR","start":23180365,"stop":23180960},{"feature_type":"CDS","start":23180961,"stop":23182239},{"feature_type":"CDS","start":23253799,"stop":23253980},{"feature_type":"CDS","start":23260950,"stop":23261054},{"feature_type":"CDS","start":23261355,"stop":23261540},{"feature_type":"CDS","start":23268408,"stop":23268515},{"feature_type":"CDS","start":23271532,"stop":23271592},{"feature_type":"CDS","start":23273081,"stop":23273133},{"feature_type":"CDS","start":23273634,"stop":23273774},{"feature_type":"CDS","start":23283977,"stop":23284098},{"feature_type":"CDS","start":23285033,"stop":23285201},{"feature_type":"CDS","start":23287159,"stop":23287278},{"feature_type":"CDS","start":23288097,"stop":23288172},{"feature_type":"CDS","start":23289517,"stop":23289621},{"feature_type":"CDS","start":23290339,"stop":23290413},{"feature_type":"CDS","start":23292541,"stop":23292638},{"feature_type":"CDS","start":23309424,"stop":23309483},{"feature_type":"CDS","start":23310324,"stop":23310433},{"feature_type":"CDS","start":23311697,"stop":23311836},{"feature_type":"CDS","start":23312887,"stop":23313021},{"feature_type":"CDS","start":23313968,"stop":23314073},{"feature_type":"CDS","start":23314552,"stop":23314714},{"feature_type":"CDS","start":23315433,"stop":23315519},{"feature_type":"UTR","start":23315520,"stop":23315950}]},{"transcript_id":"ENST00000466076","strand":"+","exons":[{"feature_type":"exon","start":23283788,"stop":23284098},{"feature_type":"exon","start":23285033,"stop":23285201},{"feature_type":"exon","start":23287159,"stop":23287173}]},{"transcript_id":"ENST00000471452","strand":"+","exons":[{"feature_type":"exon","start":23295041,"stop":23295155},{"feature_type":"exon","start":23302341,"stop":23302863}]},{"transcript_id":"ENST00000478978","strand":"+","exons":[{"feature_type":"exon","start":23306154,"stop":23306249},{"feature_type":"exon","start":23307568,"stop":23307764},{"feature_type":"exon","start":23309424,"stop":23309483},{"feature_type":"exon","start":23310324,"stop":23310433}]},{"transcript_id":"ENST00000436990","strand":"+","exons":[{"feature_type":"exon","start":23309474,"stop":23310433},{"feature_type":"exon","start":23311697,"stop":23311918},{"feature_type":"exon","start":23312887,"stop":23313021},{"feature_type":"exon","start":23313968,"stop":23314073},{"feature_type":"exon","start":23314552,"stop":23314714},{"feature_type":"exon","start":23315433,"stop":23318034}]},{"transcript_id":"ENST00000463770","strand":"+","exons":[{"feature_type":"exon","start":23198253,"stop":23198385},{"feature_type":"exon","start":23253799,"stop":23253833}]},{"transcript_id":"ENST00000419722","strand":"+","exons":[{"feature_type":"exon","start":23289615,"stop":23289621},{"feature_type":"exon","start":23292541,"stop":23292638},{"feature_type":"exon","start":23295024,"stop":23295155},{"feature_type":"exon","start":23309424,"stop":23309483},{"feature_type":"exon","start":23309943,"stop":23310433}]},{"transcript_id":"ENST00000427791","strand":"+","exons":[{"feature_type":"CDS","start":23253960,"stop":23253980},{"feature_type":"CDS","start":23260950,"stop":23261054},{"feature_type":"CDS","start":23261355,"stop":23261540},{"feature_type":"CDS","start":23271532,"stop":23271592},{"feature_type":"CDS","start":23273081,"stop":23273133},{"feature_type":"CDS","start":23273634,"stop":23273774},{"feature_type":"CDS","start":23283977,"stop":23284098},{"feature_type":"CDS","start":23285033,"stop":23285114}]},{"transcript_id":"ENST00000479188","strand":"+","exons":[{"feature_type":"exon","start":23179704,"stop":23179832},{"feature_type":"exon","start":23242818,"stop":23242985},{"feature_type":"exon","start":23253799,"stop":23253980},{"feature_type":"exon","start":23260950,"stop":23261054},{"feature_type":"exon","start":23261355,"stop":23261428}]},{"transcript_id":"ENST00000480973","strand":"+","exons":[{"feature_type":"exon","start":23251032,"stop":23251240},{"feature_type":"exon","start":23253799,"stop":23253980},{"feature_type":"exon","start":23260950,"stop":23261054},{"feature_type":"exon","start":23261355,"stop":23261393}]},{"transcript_id":"ENST00000487968","strand":"+","exons":[{"feature_type":"exon","start":23283209,"stop":23284098},{"feature_type":"exon","start":23285033,"stop":23285201},{"feature_type":"exon","start":23287159,"stop":23287278},{"feature_type":"exon","start":23288097,"stop":23288172},{"feature_type":"exon","start":23289517,"stop":23291131}]},{"transcript_id":"ENST00000305877","strand":"+","exons":[{"feature_type":"UTR","start":23180509,"stop":23180960},{"feature_type":"CDS","start":23180961,"stop":23182239},{"feature_type":"CDS","start":23253799,"stop":23253980},{"feature_type":"CDS","start":23260950,"stop":23261054},{"feature_type":"CDS","start":23261355,"stop":23261540},{"feature_type":"CDS","start":23268408,"stop":23268515},{"feature_type":"CDS","start":23271532,"stop":23271592},{"feature_type":"CDS","start":23273081,"stop":23273133},{"feature_type":"CDS","start":23273634,"stop":23273774},{"feature_type":"CDS","start":23283977,"stop":23284098},{"feature_type":"CDS","start":23285033,"stop":23285201},{"feature_type":"CDS","start":23287159,"stop":23287278},{"feature_type":"CDS","start":23288097,"stop":23288172},{"feature_type":"CDS","start":23289517,"stop":23289621},{"feature_type":"CDS","start":23290339,"stop":23290413},{"feature_type":"CDS","start":23292541,"stop":23292638},{"feature_type":"CDS","start":23295024,"stop":23295155},{"feature_type":"CDS","start":23309424,"stop":23309483},{"feature_type":"CDS","start":23310324,"stop":23310433},{"feature_type":"CDS","start":23311697,"stop":23311836},{"feature_type":"CDS","start":23312887,"stop":23313021},{"feature_type":"CDS","start":23313968,"stop":23314073},{"feature_type":"CDS","start":23314552,"stop":23314714},{"feature_type":"CDS","start":23315433,"stop":23315519},{"feature_type":"UTR","start":23315520,"stop":23318037}]},{"transcript_id":"ENST00000458056","strand":"+","exons":[{"feature_type":"exon","start":23312388,"stop":23313021},{"feature_type":"exon","start":23314552,"stop":23314695}]},{"transcript_id":"ENST00000475025","strand":"+","exons":[{"feature_type":"exon","start":23306745,"stop":23306830},{"feature_type":"exon","start":23309424,"stop":23309483},{"feature_type":"exon","start":23310324,"stop":23310433},{"feature_type":"exon","start":23311697,"stop":23311836},{"feature_type":"exon","start":23312887,"stop":23313021},{"feature_type":"exon","start":23313968,"stop":23313999}]},{"transcript_id":"ENST00000487679","strand":"+","exons":[{"feature_type":"exon","start":23198332,"stop":23198385},{"feature_type":"exon","start":23199211,"stop":23199352},{"feature_type":"exon","start":23253799,"stop":23253833}]}]},{"gene_id":"ENSG00000097007","symbol":"ABL1","name":"ABL proto-oncogene 1, non-receptor tyrosine kinase","chrom":"9","start":130713016,"stop":130887675,"strand":"+","canonical_transcript_id":"ENST00000318560","mane_select_transcript":{"ensembl_id":"ENST00000318560","refseq_id":"NM_005157"},"transcripts":[{"transcript_id":"ENST00000393293","strand":"+","exons":[{"feature_type":"UTR","start":130713980,"stop":130714319},{"feature_type":"CDS","start":130714320,"stop":130714455},{"feature_type":"CDS","start":130854067,"stop":130854122}]},{"transcript_id":"ENST00000318560","strand":"+","exons":[{"feature_type":"UTR","start":130835254,"stop":130835446},{"feature_type":"CDS","start":130835447,"stop":130835525},{"feature_type":"CDS","start":130854064,"stop":130854237},{"feature_type":"CDS","start":130854801,"stop":130855096},{"feature_type":"CDS","start":130862763,"stop":130863035},{"feature_type":"CDS","start":130872129,"stop":130872213},{"feature_type":"CDS","start":130872860,"stop":130873037},{"feature_type":"CDS","start":130874868,"stop":130875052},{"feature_type":"CDS","start":130878415,"stop":130878567},{"feature_type":"CDS","start":130880068,"stop":130880157},{"feature_type":"CDS","start":130880500,"stop":130880664},{"feature_type":"CDS","start":130883969,"stop":130885680},{"feature_type":"UTR","start":130885681,"stop":130887675}]},{"transcript_id":"ENST00000372348","strand":"+","exons":[{"feature_type":"UTR","start":130713016,"stop":130714319},{"feature_type":"CDS","start":130714320,"stop":130714455},{"feature_type":"CDS","start":130854064,"stop":130854237},{"feature_type":"CDS","start":130854801,"stop":130855096},{"feature_type":"CDS","start":130862763,"stop":130863035},{"feature_type":"CDS","start":130872129,"stop":130872213},{"feature_type":"CDS","start":130872860,"stop":130873037},{"feature_type":"CDS","start":130874868,"stop":130875052},{"feature_type":"CDS","start":130878415,"stop":130878567},{"feature_type":"CDS","start":130880068,"stop":130880157},{"feature_type":"CDS","start":130880500,"stop":130880664},{"feature_type":"CDS","start":130883969,"stop":130885680},{"feature_type":"UTR","start":130885681,"stop":130885683}]}]}],"protein":{"level":"gene","partners":[{"gene":"BCR","uniprot":"P11274","length":1271,"domains":[{"accession":"PF09036","name":"Bcr-Abl oncoprotein oligomerisation domain","interpro":"IPR015123","start":3,"end":75,"status":"unknown"},{"accession":"PF00621","name":"RhoGEF domain","interpro":"IPR000219","start":503,"end":689,"status":"unknown"},{"accession":"PF19057","name":"PH domain","interpro":null,"start":703,"end":775,"status":"unknown"},{"accession":"PF00168","name":"C2 domain","interpro":"IPR000008","start":913,"end":1007,"status":"unknown"},{"accession":"PF00620","name":"RhoGAP domain","interpro":"IPR000198","start":1068,"end":1215,"status":"unknown"}],"junction":null,"notes":[]},{"gene":"ABL1","uniprot":"P00519","length":1130,"domains":[{"accession":"PF00018","name":"SH3 domain","interpro":"IPR001452","start":67,"end":113,"status":"unknown"},{"accession":"PF00017","name":"SH2 domain","interpro":"IPR000980","start":127,"end":202,"status":"unknown"},{"accession":"PF07714","name":"Protein tyrosine and serine/threonine kinase","interpro":"IPR001245","start":242,"end":492,"status":"unknown"},{"accession":"PF08919","name":"F-actin binding","interpro":"IPR015015","start":1026,"end":1130,"status":"unknown"}],"junction":null,"notes":[]}],"frame":"not_applicable","notes":["No breakpoints were supplied, so the domains kept depend on the breakpoints. Each partner's full domain map is shown."]},"civic":{"feature":{"id":61802,"name":"BCR::ABL1","link":"/features/61802","deprecated":false,"fivePrimeGene":{"name":"BCR"},"threePrimeGene":{"name":"ABL1"},"fivePrimePartnerStatus":"KNOWN","threePrimePartnerStatus":"KNOWN"},"profiles":[{"id":1,"name":"BCR::ABL1 Fusion","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":19,"submittedCount":7}},{"id":4373,"name":"BCR::ABL1 Fusion AND ABL1 T315I","variants":[{"id":2,"name":"T315I","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":28,"submittedCount":16}},{"id":4376,"name":"BCR::ABL1 Fusion AND ABL1 F317L","variants":[{"id":1028,"name":"F317L","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":20,"submittedCount":4}},{"id":4431,"name":"BCR::ABL1 Fusion AND ABL1 E255K","variants":[{"id":3,"name":"E255K","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":19,"submittedCount":4}},{"id":4550,"name":"BCR::ABL1 Fusion AND ABL1 Y253H","variants":[{"id":4529,"name":"Y253H","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":14,"submittedCount":3}},{"id":4555,"name":"BCR::ABL1 Fusion AND ABL1 G250E","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1023,"name":"G250E","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":17,"submittedCount":4}},{"id":4556,"name":"BCR::ABL1 Fusion AND ABL1 M351T","variants":[{"id":1029,"name":"M351T","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":15,"submittedCount":4}},{"id":4673,"name":"BCR::ABL1 Fusion AND ABL1 E255V","variants":[{"id":4606,"name":"E255V","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":11,"submittedCount":6}},{"id":4730,"name":"BCR::ABL1 Fusion AND ABL1 V299L","variants":[{"id":4639,"name":"V299L","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":10,"submittedCount":1}},{"id":4719,"name":"BCR::ABL1 Fusion AND ABL1 Q252H","variants":[{"id":4634,"name":"Q252H","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":10,"submittedCount":7}},{"id":4553,"name":"BCR::ABL1 Fusion AND ABL1 D276G","variants":[{"id":4218,"name":"D276G","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":6,"submittedCount":2}},{"id":4381,"name":"BCR::ABL1 Fusion AND ABL1 F317V","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1525,"name":"F317V","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":5,"submittedCount":0}},{"id":4374,"name":"BCR::ABL1 Fusion AND ABL1 F311I","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1507,"name":"F311I","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":1}},{"id":4380,"name":"BCR::ABL1 Fusion AND ( ABL1 F317L OR ABL1 F317V )","variants":[{"id":1028,"name":"F317L","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1525,"name":"F317V","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4552,"name":"BCR::ABL1 Fusion AND ABL1 Mutation","variants":[{"id":4530,"name":"Mutation","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":4557,"name":"BCR::ABL1 Fusion AND ABL1 A365V","variants":[{"id":1607,"name":"A365V","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":4558,"name":"BCR::ABL1 Fusion AND ABL1 A366G","variants":[{"id":1608,"name":"A366G","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":4662,"name":"BCR::ABL1 Fusion AND ABL1 M244V","variants":[{"id":4597,"name":"M244V","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":14,"submittedCount":4}},{"id":4664,"name":"BCR::ABL1 Fusion AND ABL1 F359V","variants":[{"id":4598,"name":"F359V","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":15,"submittedCount":3}},{"id":4675,"name":"BCR::ABL1 Fusion AND ABL1 F359I","variants":[{"id":4607,"name":"F359I","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":6,"submittedCount":0}},{"id":4678,"name":"BCR::ABL1 Fusion AND ABL1 E355G","variants":[{"id":4609,"name":"E355G","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":8,"submittedCount":2}},{"id":4680,"name":"BCR::ABL1 Fusion AND ABL1 F359C","variants":[{"id":4610,"name":"F359C","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":9,"submittedCount":1}},{"id":4683,"name":"BCR::ABL1 Fusion AND ABL1 H396R","variants":[{"id":4611,"name":"H396R","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":10,"submittedCount":4}},{"id":4714,"name":"BCR::ABL1 Fusion AND ABL1 L248V","variants":[{"id":4632,"name":"L248V","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":9,"submittedCount":1}},{"id":4721,"name":"BCR::ABL1 Fusion AND ABL1 F486S","variants":[{"id":4635,"name":"F486S","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":6,"submittedCount":1}},{"id":4723,"name":"BCR::ABL1 Fusion AND ABL1 A397P","variants":[{"id":4636,"name":"A397P","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":1}},{"id":4725,"name":"BCR::ABL1 Fusion AND ABL1 D363G","variants":[{"id":4637,"name":"D363G","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":0}},{"id":4727,"name":"BCR::ABL1 Fusion AND ABL1 D421G","variants":[{"id":4638,"name":"D421G","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4729,"name":"BCR::ABL1 Fusion AND ABL1 E255K AND ABL1 V299L","variants":[{"id":4639,"name":"V299L","feature":{"id":4}},{"id":3,"name":"E255K","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4742,"name":"BCR::ABL1 Fusion AND ABL1 T315A","variants":[{"id":4645,"name":"T315A","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":4,"submittedCount":0}},{"id":4743,"name":"BCR::ABL1 Fusion AND ABL1 E279K","variants":[{"id":1526,"name":"E279K","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":2}},{"id":4744,"name":"BCR::ABL1 Fusion AND ABL1 E292L","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2887,"name":"E292L","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4745,"name":"BCR::ABL1 Fusion AND ABL1 E292V","variants":[{"id":1183,"name":"E292V","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":1}},{"id":4746,"name":"BCR::ABL1 Fusion AND ABL1 E450Q","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1618,"name":"E450Q","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4828,"name":"BCR::ABL1 Fusion AND ABL1 E450V","variants":[{"id":1534,"name":"E450V","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":1}},{"id":4829,"name":"BCR::ABL1 Fusion AND ABL1 E453A","variants":[{"id":1536,"name":"E453A","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":0}},{"id":4830,"name":"BCR::ABL1 Fusion AND ABL1 E453K","variants":[{"id":1535,"name":"E453K","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":1}},{"id":4832,"name":"BCR::ABL1 Fusion AND ABL1 E453Q","variants":[{"id":1509,"name":"E453Q","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4833,"name":"BCR::ABL1 Fusion AND ABL1 E459K","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2370,"name":"E459K","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":4,"submittedCount":0}},{"id":4834,"name":"BCR::ABL1 Fusion AND ABL1 E98G","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2901,"name":"E98G","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":0}},{"id":4835,"name":"BCR::ABL1 Fusion AND ABL1 F311L","variants":[{"id":1528,"name":"F311L","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":2}},{"id":4836,"name":"BCR::ABL1 Fusion AND ABL1 F317C","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2359,"name":"F317C","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4837,"name":"BCR::ABL1 Fusion AND ABL1 F317I","variants":[{"id":1625,"name":"F317I","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":1}},{"id":4838,"name":"BCR::ABL1 Fusion AND ABL1 F317R","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2888,"name":"F317R","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4839,"name":"BCR::ABL1 Fusion AND ABL1 F317S","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2343,"name":"F317S","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4872,"name":"BCR::ABL1 Fusion AND ABL1 G398R","variants":[{"id":1233,"name":"G398R","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":1}},{"id":4873,"name":"BCR::ABL1 Fusion AND ABL1 H396P","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1531,"name":"H396P","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":6,"submittedCount":5}},{"id":4874,"name":"BCR::ABL1 Fusion AND ABL1 I432T","variants":[{"id":1533,"name":"I432T","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":4875,"name":"BCR::ABL1 Fusion AND ABL1 L248R","variants":[{"id":2340,"name":"L248R","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":3,"submittedCount":0}},{"id":4876,"name":"BCR::ABL1 Fusion AND ABL1 L248R AND ABL1 F359I","variants":[{"id":2340,"name":"L248R","feature":{"id":4}},{"id":4607,"name":"F359I","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4877,"name":"BCR::ABL1 Fusion AND ABL1 L364I","variants":[{"id":1508,"name":"L364I","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":1}},{"id":4884,"name":"BCR::ABL1 Fusion AND ABL1 L364P","variants":[{"id":1530,"name":"L364P","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4885,"name":"BCR::ABL1 Fusion AND ABL1 L384M","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1230,"name":"L384M","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":3,"submittedCount":3}},{"id":4886,"name":"BCR::ABL1 Fusion AND ABL1 L387F","variants":[{"id":1232,"name":"L387F","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":3,"submittedCount":1}},{"id":4887,"name":"BCR::ABL1 Fusion AND ABL1 L387M","variants":[{"id":1488,"name":"L387M","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":1}},{"id":4888,"name":"BCR::ABL1 Fusion AND ABL1 L364I AND ABL1 M244V","variants":[{"id":1508,"name":"L364I","feature":{"id":4}},{"id":4597,"name":"M244V","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4889,"name":"BCR::ABL1 Fusion AND ABL1 M343T","variants":[{"id":1524,"name":"M343T","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4890,"name":"BCR::ABL1 Fusion AND ABL1 M388L","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1610,"name":"M388L","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4891,"name":"BCR::ABL1 Fusion AND ABL1 N146S","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2951,"name":"N146S","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4897,"name":"BCR::ABL1 Fusion AND ABL1 N331S","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1529,"name":"N331S","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":1}},{"id":4898,"name":"BCR::ABL1 Fusion AND ABL1 N336S","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1640,"name":"N336S","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":0}},{"id":4899,"name":"BCR::ABL1 Fusion AND ABL1 P480A","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1537,"name":"P480A","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4900,"name":"BCR::ABL1 Fusion AND ABL1 Q252R","variants":[{"id":1600,"name":"Q252R","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":4901,"name":"BCR::ABL1 Fusion AND ABL1 Q300R","variants":[{"id":1527,"name":"Q300R","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":2,"submittedCount":0}},{"id":4902,"name":"BCR::ABL1 Fusion AND ABL1 S417Y","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1613,"name":"S417Y","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":2}},{"id":4903,"name":"BCR::ABL1 Fusion AND ABL1 S438C","variants":[{"id":1495,"name":"S438C","feature":{"id":4}},{"id":1,"name":"Fusion","feature":{"id":61802}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":4951,"name":"BCR::ABL1 Fusion AND ABL1 T315V","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2885,"name":"T315V","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":5115,"name":"BCR::ABL1 Fusion AND ABL1 Y253F","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":4942,"name":"Y253F","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":7,"submittedCount":7}},{"id":5188,"name":"BCR::ABL1 Fusion AND ABL1 TKD Mutation","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2371,"name":"TKD Mutation","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":2}},{"id":5238,"name":"BCR::ABL1 Fusion AND ABL1 V379I","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1609,"name":"V379I","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":3,"submittedCount":2}},{"id":5241,"name":"BCR::ABL1 Fusion AND ABL1 V289I","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1604,"name":"V289I","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":1,"submittedCount":0}},{"id":5363,"name":"BCR::ABL1 Fusion AND ABL1 T315I AND ABL1 G250E","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2,"name":"T315I","feature":{"id":4}},{"id":1023,"name":"G250E","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5365,"name":"BCR::ABL1 Fusion AND ABL1 T315I AND ABL1 Y253H","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2,"name":"T315I","feature":{"id":4}},{"id":4529,"name":"Y253H","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5367,"name":"BCR::ABL1 Fusion AND ABL1 T315L","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":5109,"name":"T315L","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5369,"name":"BCR::ABL1 Fusion AND ABL1 T315M","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":5110,"name":"T315M","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5370,"name":"BCR::ABL1 Fusion AND ABL1 T315I AND ABL1 E255V","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2,"name":"T315I","feature":{"id":4}},{"id":4606,"name":"E255V","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5371,"name":"BCR::ABL1 Fusion AND ABL1 Y253H AND ABL1 E255V","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":4529,"name":"Y253H","feature":{"id":4}},{"id":4606,"name":"E255V","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5372,"name":"BCR::ABL1 Fusion AND ABL1 E255V AND ABL1 V299L","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":4606,"name":"E255V","feature":{"id":4}},{"id":4639,"name":"V299L","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5373,"name":"BCR::ABL1 Fusion AND ABL1 T315I AND ABL1 M244V","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2,"name":"T315I","feature":{"id":4}},{"id":4597,"name":"M244V","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5374,"name":"BCR::ABL1 Fusion AND ABL1 T315I AND ABL1 F359V","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2,"name":"T315I","feature":{"id":4}},{"id":4598,"name":"F359V","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5375,"name":"BCR::ABL1 Fusion AND ABL1 T315I AND ABL1 H396R","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":2,"name":"T315I","feature":{"id":4}},{"id":4611,"name":"H396R","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5376,"name":"BCR::ABL1 Fusion AND ABL1 M351T AND ABL1 V299L","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1029,"name":"M351T","feature":{"id":4}},{"id":4639,"name":"V299L","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5377,"name":"BCR::ABL1 Fusion AND ABL1 F359V AND ABL1 V299L","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":4598,"name":"F359V","feature":{"id":4}},{"id":4639,"name":"V299L","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}},{"id":5378,"name":"BCR::ABL1 Fusion AND ABL1 F317L AND ABL1 F359V","variants":[{"id":1,"name":"Fusion","feature":{"id":61802}},{"id":1028,"name":"F317L","feature":{"id":4}},{"id":4598,"name":"F359V","feature":{"id":4}}],"evidenceCountsByStatus":{"acceptedCount":0,"submittedCount":1}}],"evidence":[{"id":259,"status":"ACCEPTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":5,"disease":"Acute Myeloid Leukemia","doid":"9119","therapies":["Imatinib"],"therapyInteraction":null,"pmid":"12476305","citation":"Nimmanapalli et al., 2002","url":"https://civicdb.org/evidence/259/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":260,"status":"ACCEPTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":5,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":["Imatinib"],"therapyInteraction":null,"pmid":"20537386","citation":"An et al., 2010","url":"https://civicdb.org/evidence/260/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":344,"status":"ACCEPTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":5,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":["Imatinib"],"therapyInteraction":null,"pmid":"20537386","citation":"An et al., 2010","url":"https://civicdb.org/evidence/344/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":220,"status":"ACCEPTED","level":"A","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":4,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":[],"therapyInteraction":null,"pmid":"20537386","citation":"An et al., 2010","url":"https://civicdb.org/evidence/220/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":261,"status":"ACCEPTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":4,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":["Nilotinib","Dasatinib"],"therapyInteraction":"SUBSTITUTES","pmid":"20537386","citation":"An et al., 2010","url":"https://civicdb.org/evidence/261/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":11223,"status":"SUBMITTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":4,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":["Asciminib"],"therapyInteraction":null,"pmid":"34407542","citation":"Réa et al., 2021","url":"https://civicdb.org/evidence/11223/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":11224,"status":"SUBMITTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":4,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":["Bosutinib"],"therapyInteraction":null,"pmid":"29091516","citation":"Cortes et al., 2018","url":"https://civicdb.org/evidence/11224/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":11235,"status":"SUBMITTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":4,"disease":"B-lymphoblastic Leukemia/lymphoma","doid":"0080630","therapies":["Dasatinib"],"therapyInteraction":null,"pmid":null,"citation":"Hunger et al., 2017","url":"https://civicdb.org/evidence/11235/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":11287,"status":"SUBMITTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":4,"disease":"B-lymphoblastic Leukemia/lymphoma","doid":"0080630","therapies":["Bosutinib"],"therapyInteraction":null,"pmid":"24345751","citation":"Kantarjian et al., 2014","url":"https://civicdb.org/evidence/11287/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":11288,"status":"SUBMITTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":4,"disease":"B-lymphoblastic Leukemia/lymphoma","doid":"0080630","therapies":["Nilotinib"],"therapyInteraction":null,"pmid":"16775235","citation":"Kantarjian et al., 2006","url":"https://civicdb.org/evidence/11288/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12213,"status":"SUBMITTED","level":"A","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":4,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":["Asciminib"],"therapyInteraction":null,"pmid":"38820078","citation":"Hochhaus et al., 2024","url":"https://civicdb.org/evidence/12213/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12046,"status":"ACCEPTED","level":"B","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":4,"disease":"Acute Myeloid Leukemia With BCR-ABL1","doid":"0080976","therapies":[],"therapyInteraction":null,"pmid":"17369142","citation":"Soupir et al., 2007","url":"https://civicdb.org/evidence/12046/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12047,"status":"ACCEPTED","level":"B","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":4,"disease":"Acute Myeloid Leukemia With BCR-ABL1","doid":"0080976","therapies":[],"therapyInteraction":null,"pmid":"8952155","citation":"Cuneo et al., 1996","url":"https://civicdb.org/evidence/12047/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12048,"status":"ACCEPTED","level":"B","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":4,"disease":"Acute Myeloid Leukemia With BCR-ABL1","doid":"0080976","therapies":[],"therapyInteraction":null,"pmid":"20385793","citation":"Grimwade et al., 2010","url":"https://civicdb.org/evidence/12048/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12088,"status":"ACCEPTED","level":"B","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":4,"disease":"B-lymphoblastic Leukemia/lymphoma With BCR-ABL1","doid":"0080643","therapies":[],"therapyInteraction":null,"pmid":"10194126","citation":"Uckun et al., 1999","url":"https://civicdb.org/evidence/12088/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12089,"status":"ACCEPTED","level":"B","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":4,"disease":"B-lymphoblastic Leukemia/lymphoma With BCR-ABL1","doid":"0080643","therapies":[],"therapyInteraction":null,"pmid":"1991160","citation":"Fletcher et al., 1991","url":"https://civicdb.org/evidence/12089/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12090,"status":"ACCEPTED","level":"B","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":4,"disease":"B-lymphoblastic Leukemia/lymphoma With BCR-ABL1","doid":"0080643","therapies":[],"therapyInteraction":null,"pmid":"36050548","citation":"Brady et al., 2022","url":"https://civicdb.org/evidence/12090/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12434,"status":"SUBMITTED","level":"B","type":"PROGNOSTIC","direction":"SUPPORTS","significance":"NA","origin":"SOMATIC","rating":4,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":[],"therapyInteraction":null,"pmid":"40205062","citation":"Kamizela et al., 2025","url":"https://civicdb.org/evidence/12434/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12526,"status":"ACCEPTED","level":"B","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":4,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":[],"therapyInteraction":null,"pmid":"28404889","citation":"Luatti et al., 2017","url":"https://civicdb.org/evidence/12526/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12589,"status":"ACCEPTED","level":"B","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":4,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":[],"therapyInteraction":null,"pmid":"19737651","citation":"Bennour et al., 2009","url":"https://civicdb.org/evidence/12589/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":12087,"status":"ACCEPTED","level":"B","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","origin":"SOMATIC","rating":3,"disease":"B-lymphoblastic Leukemia/lymphoma With BCR-ABL1","doid":"0080643","therapies":[],"therapyInteraction":null,"pmid":"3455828","citation":"Bloomfield et al., 1986","url":"https://civicdb.org/evidence/12087/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":4706,"status":"ACCEPTED","level":"C","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":4,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":["Dasatinib"],"therapyInteraction":null,"pmid":"16775234","citation":"Talpaz et al., 2006","url":"https://civicdb.org/evidence/4706/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":4436,"status":"ACCEPTED","level":"C","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":3,"disease":"Acute Lymphoblastic Leukemia","doid":"9952","therapies":["Dasatinib"],"therapyInteraction":null,"pmid":"16775234","citation":"Talpaz et al., 2006","url":"https://civicdb.org/evidence/4436/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":213,"status":"ACCEPTED","level":"C","type":"DIAGNOSTIC","direction":"DOES_NOT_SUPPORT","significance":"POSITIVE","origin":"SOMATIC","rating":2,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":[],"therapyInteraction":null,"pmid":"25212276","citation":"Schmidt et al., 2014","url":"https://civicdb.org/evidence/213/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":232,"status":"ACCEPTED","level":"D","type":"PREDICTIVE","direction":"SUPPORTS","significance":"RESISTANCE","origin":"SOMATIC","rating":3,"disease":"Acute Myeloid Leukemia","doid":"9119","therapies":["Imatinib"],"therapyInteraction":null,"pmid":"12476305","citation":"Nimmanapalli et al., 2002","url":"https://civicdb.org/evidence/232/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"},{"id":7838,"status":"ACCEPTED","level":"D","type":"PREDICTIVE","direction":"SUPPORTS","significance":"SENSITIVITYRESPONSE","origin":"SOMATIC","rating":3,"disease":"Chronic Myeloid Leukemia","doid":"8552","therapies":["Nilotinib","Dasatinib","Bafetinib"],"therapyInteraction":"SUBSTITUTES","pmid":"18191450","citation":"Deguchi et al., 2008","url":"https://civicdb.org/evidence/7838/summary","scope":"variant","variantName":"BCR::ABL1 Fusion"}],"assertions":[{"id":137,"name":"AID137","status":"ACCEPTED","ampLevel":"TIER_I_LEVEL_A","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","disease":"B-lymphoblastic Leukemia/lymphoma With BCR-ABL1","therapies":[],"fdaCompanionTest":false,"url":"https://civicdb.org/assertions/137/summary"},{"id":188,"name":"AID188","status":"ACCEPTED","ampLevel":"TIER_I_LEVEL_A","type":"DIAGNOSTIC","direction":"SUPPORTS","significance":"POSITIVE","disease":"Chronic Myeloid Leukemia","therapies":[],"fdaCompanionTest":false,"url":"https://civicdb.org/assertions/188/summary"}],"truncated":false,"partnerFeatures":[{"feature":{"id":61758,"name":"v::ABL1","link":"/features/61758","deprecated":false,"fivePrimeGene":null,"threePrimeGene":{"name":"ABL1"},"fivePrimePartnerStatus":"MULTIPLE","threePrimePartnerStatus":"KNOWN"},"evidence":[{"id":6936,"status":"SUBMITTED","level":"A","type":"ONCOGENIC","direction":"SUPPORTS","significance":"ONCOGENICITY","origin":"SOMATIC","rating":4,"disease":"B-lymphoblastic Leukemia/lymphoma, BCR-ABL1–like","doid":"0080650","therapies":[],"therapyInteraction":null,"pmid":"25207766","citation":"Roberts et al., 2014","url":"https://civicdb.org/evidence/6936/summary","scope":"gene","variantName":"v::ABL1 Fusion"}],"assertions":[],"truncated":false}]},"assessment":{"call":"known_driver","label":"Known oncogenic driver (CIViC Tier I assertion, CIViC level A, FDA CDx)","reasons":[{"strength":"strong","source":"CIViC","text":"2 accepted CIViC assertions at AMP/ASCO/CAP Tier I (diagnostic in B-lymphoblastic Leukemia/lymphoma With BCR-ABL1; diagnostic in Chronic Myeloid Leukemia)."},{"strength":"strong","source":"CIViC","text":"Accepted CIViC evidence at level A (5 level A, 9 level B; predictive, diagnostic)."},{"strength":"strong","source":"FDA CDx","text":"FDA companion diagnostic for this gene pair: Tasigna (nilotinib) (Chronic Myeloid Leukemia - Peripheral Blood)."},{"strength":"supporting","source":"CIViC","text":"7 submitted (not yet accepted) CIViC items, best level A."},{"strength":"caution","source":"CIViC","text":"1 CIViC item does not support the stated significance."},{"strength":"context","source":"IntOGen","text":"BCR is a cancer driver gene in IntOGen, classed as oncogene (activating)."},{"strength":"context","source":"IntOGen","text":"ABL1 is a cancer driver gene in IntOGen, classed as tumour suppressor (loss of function)."}],"fda":[{"match":"pair","gene":"BCR::ABL1","drug":"Tasigna (nilotinib) NDA 022068","indication":"Chronic Myeloid Leukemia - Peripheral Blood","biomarker":"t(9;21) Philadelphia chromosome","details":"BCR - ABL fusion","diagnostics":["MRDx BCR-ABL Test (MolecularMD Corporation)"],"approval":"K173492 (12/22/2017)"}],"fdaListDate":"2026-10-21T14:37:03.449Z","fdaListUrl":"https://www.fda.gov/medical-devices/in-vitro-diagnostics/list-cleared-or-approved-companion-diagnostic-devices-in-vitro-and-imaging-tools"},"papers":[{"pmid":"11287972","title":"Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.","journal":"N Engl J Med","year":2001,"authors":"Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL.","citedBy":3566},{"pmid":"25476604","title":"MAGeCK enables robust identification of essential  genes from genome-scale CRISPR/Cas9 knockout  screens.","journal":"Genome Biol","year":2014,"authors":"Li W, Xu H, Xiao T, Cong L, Love MI, Zhang F, Irizarry RA, Liu JS, Brown M, Liu XS.","citedBy":2636},{"pmid":"8616716","title":"Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells.","journal":"Nat Med","year":1996,"authors":"Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, Zimmermann J, Lydon NB.","citedBy":2502},{"pmid":"17151364","title":"Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia.","journal":"N Engl J Med","year":2006,"authors":"Druker BJ, Guilhot F, O'Brien SG, Gathmann I, Kantarjian H, Gattermann N, Deininger MW, Silver RT, Goldman JM, Stone RM, Cervantes F, Hochhaus A, Powell BL, Gabrilove JL, Rousselot P, Reiffers J, Cornelissen JJ, Hughes T, Agis H, Fischer T, Verhoef G, Shepherd J, Saglio G, Gratwohl A, Nielsen JL, Radich JP, Simonsson B, Taylor K, Baccarani M, So C, Letvak L, Larson RA, IRIS Investigators.","citedBy":2481},{"pmid":"12637609","title":"Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia.","journal":"N Engl J Med","year":2003,"authors":"O'Brien SG, Guilhot F, Larson RA, Gathmann I, Baccarani M, Cervantes F, Cornelissen JJ, Fischer T, Hochhaus A, Hughes T, Lechner K, Nielsen JL, Rousselot P, Reiffers J, Saglio G, Shepherd J, Simonsson B, Gratwohl A, Goldman JM, Kantarjian H, Taylor K, Verhoef G, Bolton AE, Capdeville R, Druker BJ, IRIS Investigators.","citedBy":2421},{"pmid":"11423618","title":"Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification.","journal":"Science","year":2001,"authors":"Gorre ME, Mohammed M, Ellwood K, Hsu N, Paquette R, Rao PN, Sawyers CL.","citedBy":2265},{"pmid":"11287973","title":"Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.","journal":"N Engl J Med","year":2001,"authors":"Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, Capdeville R, Talpaz M.","citedBy":1878},{"pmid":"17126425","title":"Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance.","journal":"Biochim Biophys Acta","year":2007,"authors":"McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA.","citedBy":1766},{"pmid":"17251932","title":"Restoration of p53 function leads to tumour regression in vivo.","journal":"Nature","year":2007,"authors":"Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T.","citedBy":1503},{"pmid":"23803709","title":"European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013.","journal":"Blood","year":2013,"authors":"Baccarani M, Deininger MW, Rosti G, Hochhaus A, Soverini S, Apperley JF, Cervantes F, Clark RE, Cortes JE, Guilhot F, Hjorth-Hansen H, Hughes TP, Kantarjian HM, Kim DW, Larson RA, Lipton JH, Mahon FX, Martinelli G, Mayer J, Müller MC, Niederwieser D, Pane F, Radich JP, Rousselot P, Saglio G, Saußele S, Schiffer C, Silver R, Simonsson B, Steegmann JL, Goldman JM, Hehlmann R.","citedBy":1411}],"warnings":[],"checkedAt":"2026-11-02T14:31:43.938Z"}